The effects of artistic and social activities during hemodialysis on the life quality, pain perception, anxiety status of the patients and intradialytic complications

Introduction: We aimed to investigate the effects of social and artistic activity support on quality of life, pain perception, and anxiety status in hemodialysis (HD) patients and the relation between occupational therapy and frequent complications of HD.Methods: Volunteer instructors trained 22 patients participated in this study for wood painting for 4 hours/day, 2-3 days a week for six months. The State-Trait Anxiety Inventory (STAI I and STAI II) and Visual Analog Scale were applied before the social activity and at the 6th month. The quality of life evaluated with Short Form-36.Results: The patients who participated in the social activity more than 25 hours formed the study group (n=9), and those participated less than 25 hours made control group (n=13). There were significant differences in initial and 6th month values in both STAI I and STAI II scores of the study group, and only in STAI II score in the control group (p=0.008, p=0.015, p=0.003, respectively). In the study group, while STAI I and II mean was 49.9 and 52.8 in the first month, respectively, it decreased to 30.0 and 38.8 in 6th month, respectively. In the control group, in the first month mean of STAI II score was 56.9 and it decreased to 45.3 in the sixth month. The mean of physical function capacity from SF-36 parameters increased from 73.9 to 84.4 (p=0.026) in the study group and from 47.7 to 75.8 (p=0.002) in the control group. The difference between study and control group was statistically significant (p = 0.029). Conclusions: Our results support that social and artistic activities during HD have positive effects on chronic HD patients in terms of physical functioning level

Hemodiyaliz sırasında gerçekleştirilen sanatsal ve sosyal faaliyetlerin hastaların yaşam kalitesi, ağrı, kaygı durumları ve intradiyalitik komplikasyonlar üzerindeki etkileri

Introduction: We aimed to investigate the effects of social and artistic activity support on quality of life, pain perception, and anxiety status in hemodialysis (HD) patients and the relation between occupational therapy and frequent complications of HD.Methods: Volunteer instructors trained 22 patients participated in this study for wood painting for 4 hours/day, 2-3 days a week for six months. The State-Trait Anxiety Inventory (STAI I and STAI II) and Visual Analog Scale were applied before the social activity and at the 6th month. The quality of life evaluated with Short Form-36.Results: The patients who participated in the social activity more than 25 hours formed the study group (n=9), and those participated less than 25 hours made control group (n=13). There were significant differences in initial and 6th month values in both STAI I and STAI II scores of the study group, and only in STAI II score in the control group (p=0.008, p=0.015, p=0.003, respectively). In the study group, while STAI I and II mean was 49.9 and 52.8 in the first month, respectively, it decreased to 30.0 and 38.8 in 6th month, respectively. In the control group, in the first month mean of STAI II score was 56.9 and it decreased to 45.3 in the sixth month. The mean of physical function capacity from SF-36 parameters increased from 73.9 to 84.4 (p=0.026) in the study group and from 47.7 to 75.8 (p=0.002) in the control group. The difference between study and control group was statistically significant (p = 0.029). Conclusions: Our results support that social and artistic activities during HD have positive effects on chronic HD patients in terms of physical functioning level

Metacognitive Beliefs and Their Relation with Symptoms in Obsessive-Compulsive Disorder

Introduction: Metacognitive constructs have shown promise in explaining the symptoms of Obsessive-Compulsive Disorder (OCD). Few studies have examined the role of metacognitions in symptom dimensions of OCD, despite mounting clinical, neuropsychological and imaging evidence for the distinctiveness of these dimensions. Methods: Metacognitions were assessed using the Metacognitions Questionnaire (MCQ-30) in 51 participants with DSM IV OCD and 46 healthy controls. The Maudsley Obsessional Compulsive Inventory (MOCI) was used to quantify symptom dimensions, along with the Hamilton Anxiety Rating Scale (HAM-A) for anxiety, and Hamilton Depression Rating Scale (HAM-D) for depression. Results: Individuals with OCD differed from healthy controls on beliefs of uncontrollability and danger when depression and anxiety were controlled for. Correlations between metacognitive beliefs and obsessive-compulsive symptom dimensions were largely similar across the OCD and healthy control groups. Hierarchical regression showed that need to control thoughts contributed to checking, cleaning and rumination symptoms; cognitive self-consciousness to symptoms of slowness; uncontrollability and danger to doubt symptoms; positive beliefs to checking symptoms. Conclusions: Specific associations between metacognitive variables and the different symptom dimensions of OCD are evident, however, severity of anxiety and depression also contribute to these associations

In Vitro Antioxidant and Anticancer Activities of Some Local Plants from Bolu Province of Turkey

Polyphenolic compounds of plant origin are of growing interest in cancer prevention and treatment especially because of their antioxidant potential contributing anticarcinogenic and antimutagenic effects. The diversity of Turkeys’ flora is remarkable for the development of new nutraceuticals or pharmaceuticals. In the present study, five local underutilized plant species: Kaldırık (Trachystemon orientalis), Sirken (Chenopodium album), Yağlı Mancar (Rumex spp.1), Efelek (Rumex spp.2), Ebegümeci (Malva spp.) that are located in the Bolu Region of Turkey were investigated spectrophotometrically for total phenolic content and antioxidant capacity. Methanolic plant extracts were assessed for in vitro antioxidant activity by DPPH and CUPRAC assays. The cytotoxicity of plant extracts (100 to 1000 μg/mL) on MCT-7 cell lines were determined by MTT assay. The strongest antioxidant activities were shown for Rumex spp.1 and Rumex spp.2 with total phenolic contents of 26.71 and 16.17 mg Gallic acid equivalent/g dry weight (dw), respectively. Rumex spp.1 exhibited the highest total antioxidant capacity with 110.51 mg Trolox equivalent/g. Phenolic compound analysis done by Ultra-Fast Liquid Chromatography (UFLC) showed that both of the plants contain rutin, gallic acid, chlorogenic acid at most. The strongest cytotoxic activity was shown for Rumex spp.1 at highest concentration (1000 μg/mL) of these extracts with 56% cell viability

Is there a relation between mean platelet volume and chronic kidney disease stages in diabetic patients?

WOS: 000371356600042Objective: Chronic kidney disesase (CKD) is a state of atherosclerotic and chronic inflammation and as the estimated glomerular filtration rate (GFR) declines, cardiovascular disease (CVD) risk and inflammation increase. Mean platelet volume (MPV) has shown to be influenced by cardiovascular risk factors. The aim of this study was to evaluate the relationship between MPV and CKD. Methods: This is prospective study of a total of 812 CKD patients. Patients with CKD were assigned to into the five groups depending on estimated GFR which were calculated by Modification of Diet in Renal Disease (MDRD). Patients demographics, comorbid disease were recorded, and laboratory variables were also evaluated. Results: The mean age of CKD patients was 62.6 +/- 15.4 years. According to stages, 96 patients (11.8%) were classified as stage 1 (GFR >90 ml/min/1.73 m(2)), 77 patients (9.5%) as stage 2 (GFR 89-60 ml/min/1.73 m(2)), 306 patients (37.7%) as stage 3 (GFR 59-30 ml/min/1.73 m(2)), 198 (24.4%) patients as stage 4 (GFR 29-15 ml/min/1.73 m(2)) and 135 (16.6%) patients as stage 5 (GFR < 15 ml/min/1.73 m(2), dialysis and non-dialysis). DM was found to be positive in 299 (152 female; 147 male) patients. The mean MPV was found to higher in diabetic patients compared to non-diabetic patients (9.5 +/- 1.3 fL vs 9.3 +/- 1.4 fL, p: 0.024). There was a positive correlation between CKD stage and MPV in diabetic male patients. Conclusion: The results of our study might suggest that diabetic male patients with CKD have higher MPV values support the idea that these groups have additional risks other than CKD and these patients should be followed closely in respect to its complications

The effect of Helicobacter pylori eradication on proteinuria in patients with primary glomerulonephritis

Introduction: Glomerulonephritis is still the primary cause among the diseases causing end stage renal disease. Helicobacter pylori (HP), also having a local proinflammatory effect on gastric mucosa, can trigger a local and systemic inflammatory response, and consequently have a role in the development of extragastrointestinal defects. Material and methods: The study was composed of patients diagnosed with primary glomerulonephritis who had dyspeptic complaints throughout the diagnosis. Patients who received endoscopic biopsy upon the determination of pathologic findings in their upper gastrointestinal endoscopy were HP positive in their biopsy material. A triple eradication therapy was initiated for HP. Results: The study included 14 female and 19 male patients, 33 in total, whose biopsy material was determined to be HP positive. Before the eradication for HP, we found serum albumin to be 34.0 (19.0-51.0) g/I, serum total protein 58.6 +/- 12.9 g/l, serum creatinine 0.9 (0.5-1.2) and proteinuria 3069 (652-12392) mg/day in 24-hour urine. After the eradication, however, serum albumin was found to be 40 (20-52) g/I, serum total protein 62.3 +/- 11.1 g/l, serum creatinine 1.02 (0.6-1.29) mg/dl and proteinuria was 2850 (172-15181) mg/day in 24-hour urine. A comparison of the results showed that a statistically significant difference is established between the serum albumin, total protein and creatinine values (p = 0.001, p = 0.001 and p = 0.021, respectively), but not between proteinuria values in 24-hour urine (p = 0.990). Conclusions: Patients with primary glomerulonephritis, HP eradication treatment has an effect on serum albumin levels

The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group

Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors